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GIFSIA Research Collaborations

Redox-linked improvement of climate resilience and food crops for healthRedox-linked Improvement of Climate Resilience and Human Health Relevant Bioactives in Food Crops.

1. Traditional Native American Food and Health Research Initiatives in collaboration with American Indian Public Health Program, NDSU (Dr. Donald Warne, Director).

  • Screening of Human Health Relevant Bioactive profiles of Mesoamerican Indigenous Crops (Three Sisters, Wild Edibles, Herbs) for Dietary Management of Early Stages Type 2 Diabetes and Associated Risks.- Jacob Walker-Swaney (Ph.D)  carrying out several in vitro studies to screen phenolic bioactive-linked functionalities of Native American food crops.
  • Jacob is also conducting research on “Impact of a Traditional Seed Priming Method on Human Health Relevant Bioactives of The Three Sisters Crops”.
  • Cultural and Ecological Relevance of Healthy Community Garden with Indigenous Mesoamerican Food Crops and Herbs for Dietary Prevention and Management of Non-Communicable Chronic Diseases.
  • Current Publication from Community Garden Research Initiative: Mishra, L.K., Walker-Swaney, J., Sarkar, D., and Shetty, K. 2017. Bioactive vegetables integrated into ethnic "Three Sisters Crops" garden targeting foods for type 2 diabetes-associated heath disparities of American Indian communities. Journal of Ethnic Foods. (In Press) https://doi.org/10.1016/j.jef.2017.08.007 
  • Previous Publication: Kwon, Y-I., Apostolidis, E., Kim, Y-C. and Shetty, K. (2007). “Health benefits of traditional corn, beans and pumpkin; In vitro studies for hyperglycemia and hypertension management”. J. Medicinal Food, 10: 266-275.

2. Specialty Crop Research with winter hardy grape, berries, and small fruits of the Northern Great Plains in collaboration with Dr. Harlene Hatterman-Valenti (Specialty Horticultural Crop Research, Dept. of Plant Sciences NDSU).

  • Agriculture Product Utilization Council (APUC-North Dakota) funded research on "Advancing Value-Added Grapes and Non-Alcoholic Beverages with Human Health Benefits for North Dakota"
  • “Stress Elicited Phenolic Bioactives in Grapes and Health Relevant In Vitro Screening Targeted for Type 2 Diabetes”- Graduate Student (Ph. D, Food Safety) Ashish Christopher won best (first place) poster award in the Medicinal and Nutraceuticals Division of Association for the Advancement of Industrial Crops Annual Meeting held at Rochester, NY, from Sept. 25th-28th , 2016. Publication in International peer reviewed journal in progress.
  • Ozone-induced improvement in Human Health Relevant Bioactives in Crabapple and Heirloom Tomatoes.
  • Evaluation of Phenolic-linked Bioactive Functionality of Juneberry and Winter-Hardy Grape for Type 2 Diabetes Management.
  • Phenolic Bioactive-linked Antioxidant and Antihyperglycemic Properties of Different Berries from North Dakota- Austin Espe (Master Student) Joined Summer 2017 and currently carrying out research on different berries both from conventional and organic farming systems.

grape

 

3. Research initiatives to study human health relevant functional properties of different plant-based food systems in collaboration with Dr. Lokesh Mishra, Central Agricultural University, Meghalaya, India.

mint

4. Barley Research Initiatives in Collaboration with Dr. Paul Schwartz & Dr. Richard Horsley (Barley Breeding and Malting Quality), Dept. of Plant Sciences NDSU.

  • Evaluation of Phenolic Linked Anti-Hyperglycemic Potential of Barley (Hordeum Vulgare L.) Cultivars for the Management of Early Stages Type 2 Diabetes Using In Vitro Model”. Graduate Student (Ph. D, Cereal Science) Ramnarain Ramakrishna won travel award for oral presentation in the Medicinal and Nutraceuticals Division of Association for the Advancement of Industrial Crops Annual Meeting held at Rochester, NY, from Sept. 25th-28th, 2016.
  • Published Manuscripts
  • a) Ramakrishna, R. Sarkar, D., Schwarz, P., and Shetty, K. 2017. Phenolic linked anti-hyperglycemic bioactives of barley (Hordeum vulgare L.) cultivars as nutraceuticals targeting type 2 diabetes. Industrial Crops and Products. (In Press).
  • b) Ramakrishna, R. Sarkar, D., Manduri, A., Iyer, S.G.and Shetty, K. 2017. Improving phenolic bioactive-linked anti-hyperglycemic functions of dark germinated barley sprouts (Hordeum vulgare L.) using seed elicitation strategy. Journal of Food Science and Technology. (In Press) https://link.springer.com/article/10.1007/s13197-017-2828-9
  • “Enhancing Phenolic Antioxidant Profile of Barley Sprouts Using Bioprocessed Elicitors for Improved Bioactive Functionality In Vitro”. Graduate Student (Ph. D, Cereal Science) Ramnarain Ramakrishna won first place poster award in the “Food for Health” category at the Agricultural Bioscience International Conference Sept. 19-Sept 21, 2016 held  in the United States and Hosted by North Dakota State University in Fargo
  • Evaluation of Salinity and Water logging Resilience of Barley Cultivars.

barley

 

5. Edible Dry Bean Research Initiatives in collaboration with Dr. Juan Osorno (Edible Dry Bean Breeding Program, Dept. of Plant Sciences NDSU).

  • Climate Resilience: Screening and Improving Salinity and Waterlogging Tolerance in Edible Dry Beans Cultivars (North Harvest Bean Growers Association).
  • Publication: Orwat, J., Sarkar, D., Osorno, J. and Shetty, K. (2017). Improved salinity resilience in black bean by seed elicitation using organic compounds. Agronomy Journal, 109:1991-2003. doi:10.2134/agronj2016.12.0699).
  • Food Crops for Health: Improving Human Health Relevant Phenolic Bioactives and Associated Functionalities in Edible Dry Bean Cultivars With Pre-Harvest Natural Elicitor Treatments (North Dakota Specialty Crop Block Grant).
  • Completed Project: Master Student Jordan Orwat (Department of Plant Science, NDSU) completed study in Black Bean and submitted his thesis titled “Phenolic Antioxidant-Linked Bioactive Enrichment in Black Beans (Phaseolus vulgaris L.) to Screen for Health Benefits and Enhancement of Salinity Resilience”.

 

6. Cut Potato Seed Research Initiatives in collaboration with Dr. Edward Lulai (USDA-ARS (Northern Crop Science Laboratory, Fargo, ND)- “Redox-Linked Rapid Wound Healing of Cut-Potato Seed Tubers with Natural Bioprocessed Elicitors”.

7. Berries and Other Specialty Horticultural Fruit Crop Research Initiatives in collaboration with Dr. Floyd Woods (Department of Horticulture, Auburn University, AL).

  • Agustinah, W., Sarkar, D., Woods, F. and Shetty, K. (2016). “Apple and Blueberry Synergies for Designing Bioactive Ingredients for the Management of Early Stages of Type 2 Diabetes”. J. Food Quality, In Press (DOI: 10.1111/jfq.12206).
  • Sarkar, D., Orwat, J.,Hurburt, T.,Woods, F., Pitts, J.A. and Shetty, K. (2016) “Evaluation of Phenolic Bioactive-Linked Functionality of Blackberry Cultivars Targeting Dietary Management of Early Stages Type-2 Diabetes Using In Vitro Models”. Scientia Horticulturae, In press, DOI: 10.1016/j.scienta.2016.10.003
  • Current projects with other berries, banana, and lotus for improving human health relevant phenolic bioactive profiles.

8. Research Initiatives for Ancient North Dakota Common Emmer Wheat in collaborations with local grower, Lowell Kaul (Organic Kaul Farm, Harvey, ND, USA and ND Emmer Cooperative).

  • Evaluation of Phenolic Antioxidant-Linked Anti-Hyperglycemic Properties of North Dakota Common Emmer Wheat Using In Vitro Assays”- Graduate Student (Ph. D, Food Safety) Ashish Christopher presented poster at the Agricultural Bioscience International Conference Sept. 19-Sept 21, 2016 Hosted by North Dakota State University in Fargo
  • Future studies of phenolic bioactive–linked functionalities and its improvement in North Dakota Common Emmer Wheat at different processing and functional food design stages.

emmer wheat

9. Research initiatives with organic grain and vegetable crops in collaboration with local grower Lee and Noreen Thomas (Doubting Thomas Farm, Moorhead, MN, USA).

  • Evaluation of organic buckwheat, Teff, rolled oats, rye, and wheat for phenolic bioactive-linked functionalities by targeting dietary management of early stages type 2 diabetes and associated risks.
  • Improving organic vegetables and herbs farming practices with natural compounds.

10. Research initiatives to improve human health relevant functional properties in fruits and beverages with pre-harvest instantaneous heat-shock treatments in collaboration with Agrothermal System (Marty Fisher, CA, USA).

  • Manduri, A., Sarkar, D., Fisher, M., Vergas, C., and Shetty, K. 2016. “Instantaneous Heat Shock Treatment in Grape During Pre-Harvest Stages Enhances Phenolic-linked Medicinal Properties in Red Wine”. Journal of Medicinally Active Plants. In Press
  • Current studies with instantaneous heat shock-treated grapes, apples, and tomatoes to improve human health relevant phenolic antioxidants and associated functionalities.

agrothermal wine 1
 

11. Research initiatives to screen and evaluate phenolic-antioxidant linked anti-hyperglycemic properties of snap bean cultivars and clonal lines in collaboration with State University of Londrina (Brazil) and Dr. Jim Myers (Oregon State University, OR, USA).

  • Doctoral student, Felipe Aranha De Andrade from State University of Londrina, Brazil screened and evaluated around 100 snap bean cultivars and lines (supplied by Oregon University snap bean breeding program) for the phenolic antioxidant profiles and associated anti-hyperglycemic properties using in vitro assay models.

12. Research initiative to study phenolic bioactive profile and anti-diabetic potential of tropical fruit such as Camu-Camu in collaboration with University of Sao Paulo, Brazil.

  • Dr. Alice Fujita completed her doctoral dissertation studying on human health relevant phenolic bioactive profile of Amazonian Camu-Camu fruit and did part of her research at NDSU.
  • Fujita, A., Sarkar, D., Wu, S., Kennelly E., Shetty, K., Genovese, M-I. 2015. “Evaluation of Phenolic-linked bioactives of camu-camu (Myrciaria dubia Mc. Vaugh) for antihyperglycemia, antihypertension, antimicrobial properties and cellular rejuvenation”. Food Research International. 77:194-203.
  • The improvement of phenolic bioactive profile and human health relevant functionalities in Camu-Camu through lactic acid bacteria fermentation.

camu camu

13.  Research initiative to study phenolic bioactive profiles and anti-diabetic properties of different tropical fruits of Amazon in collaboration with Dr. Narendra Narain, Federal University of Sergipe, Brazil.

  • Dr. Suyare Ramalho studied phenolic antioxidant-linked anti-hyperglycemic properties of tropical Brazilian Fruits (Acai, jaboticaba, jambolan, persimmon, Surinam cherry) as potential target for dietary management of early stages of type 2 diabetes.
  • Further, the improvement of phenolic antioxidant-linked functionalities of these fruits through lactic acid bacteria fermentation was also evaluated.

14. Andean and other Mesoamerican crop research initiatives in collaboration with Dr. Lena Galvez Ranilla, Universidad Nacional Agraria La Molina (UNALM), Lima, Peru.

  • Ranilla, L.G., Apostolidis, E., Genovese, M.I., Lajolo, F.M. and Shetty. K. (2009). “Evaluation of indigenous grains from the Peruvian Andean region for anti-diabetes and antihypertension potential using in vitro methods.” J. Medicinal Food, 12: 704-713.
  • Ranilla, L.G., Kwon, Y-I., Apostolidis, E. and Shetty. K. (2010). “Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America.” Bioresource Technology, 101: 4676–4689.
  • Ranilla, L.G., Apostolidis, E. and Shetty, K. (2012). “Ultraviolet Protective Properties of Latin American Herbs in Saccharomyces cerevisiae and likely mode of action through the proline-linked pentose phosphate pathway: Focus on the Yerba Mate Tea (Ilex paraguariensis).” Journal of Food Biochemistry, 36: 322-333.
  • Ranilla, L.G., Apostolidis, E. and Shetty. K. (2012). “Antimicrobial Activity of an Amazon Medicinal Plant (Chancapiedra) (Phyllanthus niruri L.) against Helicobacter pylori and Lactic Acid Bacteria.” Phytotherapy Research, 26: 791-799.
  • Gonzalez-Muñoz A, Quesille-Villalobos AM, Fuentealba C, Shetty K, Galvez Ranilla L.(2013) “Potential of Chilean native corn (Zea mays L.) accessions as natural sources of phenolic antioxidants and in vitro bioactivity for hyperglycemia and hypertension management.” J. Agric Food Chem. 61: 10995-11007.
  • Fuentealba,C., Quesille-Villalobos, A.M., González-Muñoz, A., Torrico, J.S., Shetty, K. and Ranilla. L.G. (2016). “Optimized methodology for the extraction of free and bound phenolic acids from Chilean Cristalino corn (Zea mays L.) accession,” CyTA - Journal of Food, In press, DOI: 10.1080/19476337.2016.1217048.

14. Research initiatives for evaluation of phenolic antioxidants and human health relevant functionalities of tropical Central American Fruit Crops in collaboration with Dr. Victor Jimenez and Dr. Patricia Esquivel from University of Costa Rica, Costa Rica.

15. Research initiatives for evaluating human health relevant functional properties and antimicrobial potentials of fermented foods, condiments, and spices of Western and Central Africa in collaboration with Dr. Abiodun Sanni & Dr. Kolawole Banwo, University of Ibadan, Nigeria.

16. Anthocyanin enriched food for health research initiatives in collaboration with Dr. De-Xing Hou, Kagoshima University, Japan.

17.  Research Initiatives focusing on animal and clinical studies to screen nutraceutical and functional health relevant profiles of major foods of India and other Asian countries research initiatives in collaboration with Dr. KNC Murthy, MS Ramiah Medical College and Hospitals, Bangalore, India and National Institute of Animal Nutrition and Physiology in Bangalore, India.

18. Research Initiatives to improve climate resilience in major food crops of South-East Asian countries in collaboration with Chiang Mai University, Thailand, Udayana University, Indonesia, and University of Agricultural Science Bangalore & Dharwad, India.

19. Research initiatives to study human health benefits of fermented foods of South East Asia in collaborations with Dr. Chartchai, Khanongunch, Chiang Mai University, Thailand.

20. Research Initiatives on clinical validation of functional and fermented foods in collaboration with Chonbuk National University in South Korea.

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