Chung S. Park
Professor

Office: 193 Hultz Hall
Phone: (701) 231-7670
E-mail: c.park@ndsu.edu

A.    Research interests:

Maternal nutrition and epigenetic imprint in mammary development, lactation, and mammary tumorigenesis.

B.     Education/Training:

Seoul National University                            Animal Science                 BS                     1964
University of Georgia, Athens                      Animal Nutrition                 MS                    1972
Virginia Tech & State Univ., Blacksburg       Nutritional Physiology         PhD                   1975
Virginia Tech & State Univ., Blacksburg       Lactation Physiology          Postdoctorate     1975/77
Purdue University, W. Lafayette                  Mammary Biology              Postdoctorate     1977/78

C.    Professional Positions:

1978-1982          Assistant Professor, Dept. of Animal Sciences, North Dakota State University, Fargo

1982-1988          Associate Professor, Dept. of Animal Sciences, North Dakota State University, Fargo

1985-1986          Visiting Professor, Dept. of Medicine/Oncology, Stanford University Medical School, Stanford (Dr. Frank Stockdale)

1986-1986          Visiting Professor, Dept. of Cell Biology, Lawrence Berkeley Laboratory, University of California, Berkeley (Dr. Mina Bissell)

1994-1994          Interim Chair, Dept. of Animal Sciences, North Dakota State University, Fargo

1988-present      Professor, Dept. of Animal Sciences, North Dakota State University, Fargo

D.    Selected Peer-reviewed Publications:
(From a total of 67 refereed journals/book articles; 6 invited)

1. Wiens, D., C.S. Park, and F.E. Stockdale. 1987. Milk protein expression and ductal morphogenesis in the mammary gland in vitro: Hormone-dependent and -independent phases of adipocyte-mammary epithelial cell interaction. Dev Biol 120:245-258.
2. Aggeler, J., C.S. Park, and M.J. Bissell. 1988. Regulation of milk protein and basement membrane gene expression: The influence of the extracellular matrix. J Dairy Sci 71:2830-2842.
3. Choi, C.B., M.G. Baik, W.L. Keller, and C.S Park. 1993. Lipotrope-modified diets enhance nitrosomethylurea-induced mammary carcinogenesis in female rats. Nutr Cancer 20:215-221.
4. Park, C.S., C.B. Choi, M.G. Baik, and W.L. Keller. 1994. Modulation of expression of fos and Ha-ras oncogenes and ornithine decarboxylase activity in mammary gland and liver of young female rats by the absence of dietary lipotropes. J Dairy Sci 77:2214-2220.
5. Moon, Y.S., W.L. Keller, and C.S. Park. 1998. Dietary lipotrope-mediated mammary carcinogenesis in female rats. Nutr Res 18:1605-1614.
6. Wu, D., W.L. Keller, and C.S. Park. 1998. Lipotrope deficiency inhibits cell growth and induces programmed cell death in human breast cancer cell line MCF-7. Nutr Cancer 32:13-19.
7. Park, C.S., and G.L. Lindberg. 2004. The Mammary Gland and Lactation. Pages 720-741 in Dukes’ Physiology of domestic Animals 12^th ed. (W.O. Reece, ed.) Cornell University Press, Ithaca, NY.
8. Park, C.S. 2005. Role of compensatory mammary growth in epigenetic control of gene expression. FASEB J 19:1586-1591.
9. Park, C.S., K.S. Cho, D.R. Bae, N.E. Joo, H.H. Kim, L. Mabasa, and A.W. Fowler. 2008. Methyl-Donor Nutrients Inhibit Breast Cancer Cell Growth. In Vitro Cell Dev Biol-Anim 44:268-272.
10. Cho, K., L. Mabasa, A.W. Fowler, D.M. Walsh, and C.S. Park. 2010. Canola Oil Inhibits Breast Cancer Cell Growth in Cultures and In Vivo and Acts Synergistically with Chemotherapeutic Drugs. Lipids 45:777-784.
11. Park, C.S. 2010. Lipotropes (Folate, Vitamin B-12, Methionine and Choline) Reduce Breast Cancer Risk. Pages 133-139. In Advances in Medicine and Biology, Vol. 12 (L.V. Berhardt, ed.). Nova Science Publishers, Hauppague, NY.
12. Mabasa, L., K. Cho, S. Bae, D.M. Walsh, and C. S. Park. 2011. Lipotropes (Methyl Nutrients) Inhibit Growth of Feline Lymphoma in Vitro. Res Vet Sci. 93:259-263.
13. Cho, K., L. Mabasa, S. Bae, M.W. Walters, and C.S. Park. 2012. Maternal High Methyl Diet Suppresses Mammary Carcinogenesis in Female Rat Offspring. Carcinogenesis 33:1106-1112.
14. Mabasa, L., K. Cho, M.W. Walters, and C.S. Park. 2013. Maternal Dietary Canola Oil Suppresses Growth of Mammary Carcinogenesis in Female Rat Offspring. Nutr Cancer [In Press].
15. Cho, K., L. Mabasa, M.W. Walters, and C.S. Park. 2013. Lipotropes enhance the anti-proliferative effect of chemotherapeutic drugs in MCF-7 human breast cancer cells. Oncol Rep [In Press].

E.     Teaching:

ANSC 488 - Dairy Production (Undergraduate capstone course): 1994-2011
ANSC 721 - Biology of Lactation (Graduate course): 1979-present