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Anna Grazul-Bilska

Anna Grazul-Bilska

 

 

 

 

 

 

 

Anna Grazul-Bilska
Professor

Office: 189 Hultz Hall
Phone: (701) 231-7992
E-mail: anna.grazul-bilska@ndsu.edu

Research interests:
Animal Embryology, Reproductive Physiology and Endocrinology, Assisted Reproductive Technology, Cellular Interactions in Physiological and Pathological Conditions

Training/Education:
Postdoctoral research , Department of Animal and Range Sciences, North Dakota State University, 1986-1989.

Ph.D. , Reproductive Physiology - University of Agriculture and Technology, Olsztyn , Poland , 1983.
M.S. , Animal Genetics - University of Agriculture and Technology, Olsztyn , Poland , 1974.
B.S. , Animal Science - University of Agriculture and Technology, Olsztyn , Poland , 1973.

Courses taught:
ANSC 455 - Animal Biotechnology (Syllabus-word format or .pdf format)

Selected publications (book chapters, refereed reviews and original articles)

A.        Book Chapters:

  1. AT Grazul-Bilska, DA Redmer and LP Reynolds. Growth factors during ovarian angiogenesis. In: Vascular Morphogenesis in the Female Reproductive System (H. Augusitin, L. Ituela-Arispe, P. Rogers, S. Smith, eds), Springer Verlag, pp. 131-147, 2001.
  2. Reynolds LP, Redmer DA, Grazul-Bilska AT. 2005. The Microvasculature of the Ovary. In: Microvascular Research: Biology and Pathology (PA D’Amore et al., eds. [D Shepro Ed.-in-Chief]), Academic Press/Elsevier, NY (ISBN 0-12-639510-1), 2005.
  3. Grazul-Bilska AT, DA Redmer and LP Reynolds. Growth factors during ovarian angiogenesis. In: Vascular Morphogenesis in the Female Reproductive System (H. Augusitin, L. Ituela-Arispe, P. Rogers, S. Smith, eds), Springer Verlag, pp. 131-147, 2001.
  4. Reynolds LP, Redmer DA, Grazul-Bilska AT. 2005. The Microvasculature of the Ovary. In: Microvascular Research: Biology and Pathology (PA D’Amore et al., eds. [D Shepro Ed.-in-Chief]), Academic Press/Elsevier, NY (ISBN 0-12-639510-1), 2005.

B.        Review Articles:

    1. Grazul-Bilska AT, LP Reynolds, A Jablonka-Shariff and DA Redmer. Cellular interactions in luteal tissues: Role of gap junctions. Assisted Reproductive Technology/Andrology, 6:264-286, 1994. Invited.
    2. Grazul-Bilska AT, LP Reynolds and DA Redmer. Gap junctions in the ovaries. Minireview. Biol. Reprod.57:947-957, 1997.
    3. Grazul-Bilska AT, DA Redmer and LP Reynolds. Cellular interactions within the corpus luteum. Semin. Reprod. Endocrinol. 15:383-393, 1997. Invited.
    4. Reynolds LP, AT Grazul-Bilska and DA Redmer. Angiogenesis in the corpus luteum. Endocrine 12:1-9, 2000.
    5. Reynolds LP, AT Grazul-Bilska and DA Redmer. Angiogenesis in the female reproductive system: Pathological implications. Invited. Int. J. Exp. Pathol. 83:151-164, 2002.
    6. Grazul-Bilska AT, ML Johnson, JJ Bilski, DA Redmer, LP Reynolds, A Abdullah and KM Abdullah. Wound healing: The role of growth factors. Drugs of Today. 39:787-800, 2003. Invited.
    7. Reynolds LP, JS. Caton, DA. Redmer, AT Grazul-Bilska, KA. Vonnahme, PP. Borowicz, JS Luther, JM Wallace, G Wu, and TE. Spencer. Evidence for altered placental blood flow and vascularity in compromised pregnancies. Journal of Physiology, 572: 51-58, 2006.
    8. Reynolds LP, Borowicz PP, Caton JS, Vonnahme KA, JS. Luther, CJ Hammer, KR Maddock Carlin, Grazul-Bilska AT and Redmer DA. Developmental programming: The concept, large animal models, and the key role of utero-placental vascular development. J. Anim. Sci. 88: E61-E72, 2010.
    9. Reynolds LP, KA Vonnahme, CO Lemley, DA Redmer, AT Grazul-Bilska, PP Borowicz and JS Caton. Maternal Stress and Placental Vascular Function and Remodeling. Invited review. Current Vascular Pharmacology, Thematic Issue ‘Uteroplacental Circulation and Fetal Vascular Function and Development,” L Zhang (ed.) 11: 564-593, 2013.
    10. Reynolds LP, PP Borowicz, C Palmieri and AT Grazul-Bilska. Placental Vascular Defects in Compromised Pregnancies: Effects of Assisted Reproductive Technologies and Other Maternal Stressors. Adv Exp Med Biol 814:193-204, 2014.

      C.        Refereed Journal Articles:

        1. Grazul AT, JD Kirsch, WD Slanger, MJ Marchello and DA Redmer: Prostaglandin F2α, oxytocin and progesterone secretion by bovine luteal cells at several stages of luteal development: Effects of oxytocin, luteinizing hormone, prostaglandin F2α and estradiol-17β.  Prostaglandins 38:307-318, 1989.
        2. Grazul-Bilska AT, DA Redmer and LP Reynolds: Secretion of   angiogenic activity and progesterone by ovine luteal cell types in vitro.  J. Anim. Sci.  69:2099-2107, 1991.
        3. Grazul-Bilska AT, LP Reynolds, WD Slanger and DA Redmer.  Production of heparin-binding angiogenic factor(s) by bovine corpora lutea during pregnancy.  J. Anim. Sci. 70:254-262, 1992.
        4. Grazul-Bilska AT, DA Redmer, SD Killilea, KC Kraft and LP Reynolds.  Production of mitogenic factor(s) by ovine corpora lutea throughout the estrous cycle.  Endocrinology 130:3625-3632, 1992.
        5.  Grazul-Bilska AT, DA Redmer, A Jablonka-Shariff, ME Biondini and LP Reynolds. Proliferation and progesterone production of ovine luteal cells throughout the estrous cycle: Effects of fibroblast growth factors (FGF), luteinizing hormone (LH) and fetal bovine serum (FBS). Can. J. Physiol. Pharmacol. 73:491-500, 1995.
        6. Grazul-Bilska AT, LP Reynolds, JD Kirsch and DA Redmer. Gap junctional intercellular communication of bovine luteal cells from several stages of the estrous cycle: Effects of cyclic adenosine 3',5'-monophosphate. Biol. Reprod. 54:538-545, 1996.
        7. Grazul-Bilska AT, LP Reynolds, ML Johnson, A Jablonka-Shariff, JJ Bilski and DA Redmer. Gap junctional protein connexin 43 in bovine corpora lutea throughout the estrous cycle. Biol. Reprod. 54:1279-1287, 1996.
        8. Grazul-Bilska AT, DA Redmer, JJ Bilski, A Jablonka-Shariff, V Doraiswamy and LP Reynolds.  Gap junctional proteins, connexin 26, 32 and 43 in sheep ovaries throughout the estrous cycle. Endocrine, 8:269-279, 1998.
        9.  Abdullah KM, G Lutra, JJ Bilski, SA Abdullah, LP Reynolds, DA Redmer and AT Grazul-Bilska.  Cell-to-cell communication and expression of gap junctional proteins in human diabetic and non-diabetic fibroblasts: Effects of basic fibroblast growth factor. Endocrine, 10:35-41, 1999.
        10. Johnson ML, DA Redmer, LP Reynolds and AT Grazul-Bilska. Expression of gap junctional proteins connexin 43, 32, and 26 throughout follicular development and atresia in cows. Endocrine, 10:43-51, 1999.
        11. Stenbak TK, DA Redmer, HR Berginski, AS Erickson, C Navanukraw, MJ Toutges, JJ Bilski, JD Kirsch, KC Kraft, LP Reynolds, and AT Grazul-Bilska. Effects of follicle stimulating hormone (FSH) on follicular development, oocyte retrieval, and in vitro fertilization (IVF) in ewes during breeding season and seasonal anestrous. Theriogenology 56:51-64, 2001.
        12. Grazul-Bilska AT, LP Reynolds, JJ Bilski and DA Redmer.  Effects of second messengers on gap junctional intercellular communication of ovine luteal cells throughout the estrous cycle. Biol. Reprod. 65:777-783, 2001.
        13. Grazul-Bilska AT, G Luthra, LP Reynolds, JJ Bilski, ML Johnson, SA Abdullah, DA Redmer and KM Abdullah.  Effects of basic fibroblast growth factor (FGF-2) on proliferation of human skin fibroblasts in diabetes mellitus. Exp. Clin. Endocrinol. Diab. 110:176-181, 2002.
        14. Grazul-Bilska AT, JT Choi, JJ Bilski, RM Weigl, JD Kirsch, KC Kraft, LP Reynolds and DA Redmer. Effects of epidermal growth factor on early embryonic development after in vitro fertilization of oocytes collected from ewes treated with follicle stimulating hormone. Theriogenology 59:1453-1461, 2003.
        15. Abdullah KM, A Abdullah, ML Johnson, JJ Bilski, K Petry, DA Redmer, LP Reynolds, and AT Grazul-Bilska. Effects of aloe vera on gap junctional intercellular communication (GJIC) and proliferation of human diabetic and non-diabetic skin fibroblasts. Journal of Alternative and Complementary Medicine. 9:711-718, 2003.
        16. Luther JS, DA Redmer, LP Reynolds, JT Choi, D Pant, C Navanukraw, D Arnold, AN Scheaffer, P Borowicz JD Kirsch, RM Weigl, KC Kraft, and AT Grazul-Bilska. Ovarian follicular development and oocyte quality in anestrous ewes treated with melatonin, controlled internal drug release (CIDR) device and follicle stimulating hormone. Theriogenology 63: 2136-2146, 2005.
        17. Pant D, LP. Reynolds, JS. Luther, PP. Borowicz, T Stenbak, JJ Bilski, RM. Weigl, F Lopes, ML Johnson, DA Redmer, and AT Grazul-Bilska.  Expression of connexin 43 and gap junctional intercellular communication in cumulus oocyte complex in sheep.  Reproduction 129:191-200, 2005. http://www.reproduction-online.org/cgi/reprint/129/2/191
        18. Grazul-Bilska AT, D Pant, JS Luther, JT Choi, P Borowicz, C Navanukraw, JD Kirsch, K.C. Kraft, RM Weigl, DA Redmer and LP Reynolds. Pregnancy rates and gravid uterine parameters in single, twin and triplet pregnancies in naturally bred ewes and ewes after transfer of in vitro produced embryos. Animal Reproduction Sciences, 92: 268-283, 2006.
        19. Borowczyk E, JS Caton, DA Redmer, JJ Bilski, RM Weigl, KA Vonnahme, PP Borowicz, LP Reynolds, and AT Grazul-Bilska. Effects of plane of nutrition on in vitro fertilization (IVF) and early embryonic development in sheep.  Journal of Animal Sciences, 84: 1593-1599, 2006.
        20. Vonnahme KA, DA Redmer, E Borowczyk, JJ Bilski, ML Johnson, LP Reynolds and AT Grazul-Bilska. Vascular composition, apoptosis, and expression of angiogenic factors in the corpus luteum during prostaglandin F - induced regression in sheep. Reproduction 131: 1115-1126, 2006.
        21. Borowczyk E, Johnson ML, JJ Bilski, PP Borowicz, DA Redmer, LP Reynolds and AT Grazul-Bilska.  Expression of mRNA for gap junctional connexins 26, 32 and 43 in ovarian preovulatory follicles and corpora lutea in sheep. Canadian Journal of Physiology and Pharmacology 84: 1011-1020; 2006.
        22.  Grazul-Bilska AT, C Navanukraw, ML Johnson, DA Arnold, LP Reynolds, and DA Redmer. Expression of endothelial nitric oxide synthase (eNOS) in the ovine ovary throughout the estrous cycle. Reproduction, 132: 579-587, 2006.
        23. Borowczyk E, Johnson ML, Redmer DA, Reynolds LP, JJ Bilski, and AT Grazul-Bilska,.  Gap junctional connexins 37 is expressed in sheep ovaries. Endocrine 30: 223-230, 2006.
        24. Borowczyk E, Johnson ML, JJ Bilski, MA Bilska, PP Borowicz, Redmer DA, Reynolds LP and Grazul-Bilska AT.  Role of gap junctions in regulation of progesterone secretion by luteal cells in vitro.  Reproduction, 133: 641-651, 2007
        25. AT Grazul-Bilska, C Navanukraw, ML Johnson, KA Vonnahme, SP Ford, LP Reynolds and DA Redmer. Vascularity and expression of angiogenic factors in bovine dominant follicles of the first follicular wave. Journal of Animal Sciences, 85: 1914-1922, 2007.
        26. Grazul-Bilska AT, JD Kirsch, JJ Bilski, KC Kraft, EJ Windorski, JS Luther, KA Vonnahme, LP Reynolds and DA Redmer. Superovulation in sheep: Number and weight of the corpora lutea and serum progesterone. Sheep and Goat Research Journal 22: 26-31, 2007;
        27. Vonnahme KA, J Evoniuk, ML Johnson, PP Borowicz, DA Redmer, LP Reynolds and AT Grazul-Bilska. Placental vascularity and growth factor expression in singleton, twin, and triplet pregnancies in the sheep. Endocrine, 33: 53-61, 2008.
        28. Grazul-Bilska AT, J Banerjee, I Yazici, E Borowczyk, JJ Bilski, RK Sharma, M Siemionov, T Falcone. Morphology and function of cryopreserved whole ovine ovaries after heterotopic autotransplantation. Reproductive Biology and Endocrinology, 6: 16; 2008.
        29. Grazul-Bilska AT, JS Caton, W Arndt, K Burchill, C Thorson, E Borowczyk, JJ Bilski, DA Redmer, LP Reynolds and KA Vonnahme. Cellular proliferation in ovine fetal ovaries: Effects of energy restrictions and selenium in maternal diet. Reproduction, 137:699-707, 2009.
        30. Grazul-Bilska AT, JJ Bilski, DA Redmer, LP Reynolds, KM Abdullah, and A Abdullah. Antioxidant capacity of 3D human skin EpiDermTM model: effects of skin moisturizers. International Journal of Cosmetic Sciences, 31:201-208, 2009.
        31. Grazul-Bilska AT, ML Johnson, JJ Bilski, KM Abdullah and A Abdullah. Effects of aloe vera on expression of fibroblast growth factor receptor 2 IIIc mRNA by human diabetic and non-diabetic skin fibroblasts. Journal of Alternative Medicine Research, 2: 215-221, 2010.
        32. Grazul-Bilska AT, PP Borowicz, ML Johnson, MA Minten, JJ Bilski, R Wroblewski, DA Redmer and LP Reynolds. Placental development during early pregnancy in sheep: Vascular growth and expression of angiogenic factors in maternal placenta. Reproduction, 140:165-174, 2010.
        33. A Germeyer, M von Wolff, J Jauckus, T Strowitzki, T Sharma and AT Grazul-Bilska. Changes in cell proliferation, but not in vascularisation are characteristic for human endometrium in different reproductive failure. Reproductive Biology and Endocrinology, 8:67, 2010.
        34. Grazul-Bilska AT, ML Johnson, PP Borowicz, M Minten, JJ Bilski, R Wroblewski, M Velimirovich, LR Coupe, DA Redmer and LP Reynolds. Placental development during early pregnancy in sheep: Cell proliferation, global methylation and angiogenesis in fetal placenta. Reproduction, 141: 529-540, 2011.
        35. Grazul-Bilska AT, KA Vonnahme, JJ Bilski, E Borowczyk, D Soni, B Mikkelson, ML Johnson, LP Reynolds, DA Redmer and JS Caton. Expression of gap junctional connexin proteins in ovine fetal ovaries: Effects of maternal diet. Domestic Animal Endocrinology, 41:185-194; 2011.
        36. Einarsson JI, KA Vonnahme, Sandberg EM, AT Grazul-Bilska. Barbed vs. Standard Suture: effects on cellular composition and proliferation of the healing wound in the ovine uterus. Acta Obstetricia et Gynecologica Scandinavica, 91:613-619, 2012.
        37. Grazul-Bilska AT, E Borowczyk, JJ Bilski, LP Reynolds, DA Redmer, JS Caton and KA Vonnahme. Overfeeding and underfeeding have detrimental effects on oocyte quality measured by in vitro fertilization and early embryonic development in sheep. Domest Anim Endocrinol 43: 289–298, 2012.
        38. Wiesak T, AT Grazul-Bilska, M Wikarczuk, JS Schinfeld, LI Barmat, A Lee and SG Somkuti. Prognosis for clinical pregnancy and birth after transferring embryos derived from a cohort of incompletely mature oocytes at retrieval time. Reprod Biol 12: 219-229, 2012.
        39. Grazul-Bilska AT, ML Johnson, PP Borowicz, L Baranko, DA Redmer and LP Reynolds. Placental development during early pregnancy in sheep: Effects of embryo origin on fetal and placental growth, and global methylation. Theriogenology, 79:94-102, 2013.
        40. Grazul-Bilska AT, PP Borowicz, LP Reynolds, and DA Redmer. Vascular perfusion method to study angiogenesis and expression of regulatory factors in ovaries. Acta Histochemica 115: 893-898, 2013.
        41. Grazul-Bilska AT, TL Neville, E Borowczyk, A Sharma, LP Reynolds, JS Caton, DA Redmer, and KA Vonnahme. Ovarian and uterine characteristics and onset of puberty in adolescent offspring: Effects of maternal diet and Se supplementation in sheep. Theriogenology 81:887-895, 2014.
        42. Kaminski SL, AT Grazul-Bilska, EK Harris, EP Berg, KA Vonnahme. Impact of maternal physical activity during gestation on porcine fetal, neonatal, and adolescent ovarian development. Domestic Animal Endocrinology 48:56-61, 2014.
        43. Grazul-Bilska AT, MLynn Johnson, PP Borowicz, JJ Bilski, T Cymbaluk, SS Norberg, DA Redmer and LP Reynolds. Placental development during early pregnancy in sheep: Effects of embryo origin on vascularization of the placenta. Reproduction 147:639-649, 2014.
        44. KE Quinn; AK Ashley, LP Reynolds, AT Grazul-Bilska and R Ashley.  Activation of the CXCL12/CXCR4 signaling axis may drive vascularization of the ovine placenta.  Domestic Animal Endocrinology 47:11-21, 2014.
        45. ML Johnson, AT Grazul-Bilska, LP Reynolds, and DA Redmer. Prion (PrPC) expression in ovine uteroplacental tissues increases after estrogen treatment in ovariectomized ewes and during early pregnancy. Reproduction 148:1-10; 2014.
        46. SL Kaminski, DA Redmer, C Bass, DH Keisler, KA Vonnahme, ST Dorsam and AT Grazul-Bilska. Metabolic and reproductive hormones, and selected metabolites in serum of overfed or underfed ewes treated with arginine during the estrous cycle. Theriogenology, in press, 2015.
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